Which species is most commonly associated with fumonisin-induced GI signs?

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Get ready for the ACVPM Toxicology Exam with our comprehensive quiz. Enhance your knowledge with multiple-choice questions and detailed explanations. Prepare effectively for your certification exam!

Multiple Choice

Which species is most commonly associated with fumonisin-induced GI signs?

Explanation:
Fumonisins disrupt sphingolipid metabolism by inhibiting ceramide synthase, which damages rapidly renewing tissues like the gastrointestinal mucosa. In ruminants, this often shows up as GI upset when contaminated feed is eaten—reduced appetite, abdominal discomfort, and diarrhea with potential weight loss. Other species tend to have different primary toxic effects: horses typically develop neurologic signs (leukoencephalomalacia), pigs more often show pulmonary edema, and poultry can have hepatic or other systemic effects. So, when fumonisin exposure is linked to GI signs, ruminants are the most commonly affected group.

Fumonisins disrupt sphingolipid metabolism by inhibiting ceramide synthase, which damages rapidly renewing tissues like the gastrointestinal mucosa. In ruminants, this often shows up as GI upset when contaminated feed is eaten—reduced appetite, abdominal discomfort, and diarrhea with potential weight loss. Other species tend to have different primary toxic effects: horses typically develop neurologic signs (leukoencephalomalacia), pigs more often show pulmonary edema, and poultry can have hepatic or other systemic effects. So, when fumonisin exposure is linked to GI signs, ruminants are the most commonly affected group.

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