What are the primary clinical signs of pyrethrin/pyrethroid toxicosis in animals?

• A. GI disturbances with vomiting
• B. Neurological signs, with potential resolution or death within 24-72 hours
• C. Cardiovascular collapse
• D. Skin lesions only

Answer: (B)

Neurological signs are the main clinical feature because pyrethroid compounds alter voltage-gated sodium channels in nerve membranes, causing prolonged depolarization and repetitive firing. This leads to tremors, ataxia, restlessness or agitation, heightened sensitivity to touch, and, in more severe cases, seizures. GI signs like vomiting can occur but are not the defining problem. The course typically unfolds over hours to a couple of days, and with prompt decontamination and supportive care many animals recover within 24–72 hours; however, severe exposures can progress to fatal CNS depression or seizures within that same time frame. Cardiovascular collapse is not the primary presentation, and skin lesions are not characteristic of systemic pyrethroid toxicosis.