What are clinical signs due to organochlorine poisoning?

• A. Neuro, primarily
• B. Gastrointestinal symptoms only
• C. Cardiovascular symptoms
• D. Dermatologic signs

Answer: (A)

Organochlorine poisoning is primarily neurotoxic. These compounds readily reach the brain and disrupt neuronal function, leading to CNS excitation and impaired inhibition. The most characteristic clinical signs are neuro abnormalities: tremors and hyperactivity that can progress to incoordination, ataxia, exaggerated reflexes, and, with higher exposure, seizures or altered mental status. While gastrointestinal symptoms can occur, they are not the defining feature of organochlorine toxicity. Cardiovascular and dermatologic signs are not the hallmark presentations. Mechanistically, many organochlorines interfere with GABAergic inhibition and alter sodium channel function, promoting ongoing neuronal firing. This makes neuro signs the best and most consistent clue to organochlorine poisoning.